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Biological activities of Prunella vulgaris extract
Author(s) -
Psotová Jitka,
Kolář Milan,
Soušek Jaromír,
Švagera Zdeněk,
Vičar Jaroslav,
Ulrichová Jitka
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1324
Subject(s) - rosmarinic acid , prunella vulgaris , dpph , hacat , antioxidant , antimicrobial , haemolysis , caffeic acid , traditional medicine , in vitro , chemistry , biochemistry , biological activity , biology , microbiology and biotechnology , medicine , alternative medicine , traditional chinese medicine , pathology , immunology
The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)‐mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert ‐butyl hydroperoxide, or to Cu(II) and Fe(III) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB 4 in bovine PMNL generated by the 5‐lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal broblasts and a moderate OF antimicrobial activity on gram‐positive bacteria. Rosmarinic, caffeic and 3‐(3,4‐dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of P. vulgaris . Copyright © 2003 John Wiley & Sons, Ltd.