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Toxicity and antiviral activity of cinnabarin obtained from Pycnoporus sanguineus (Fr.) Murr
Author(s) -
Smânia A.,
Marques C. J. S.,
Smânia E. F. A.,
Zanetti C. R.,
Carobrez S. G.,
Tramonte R.,
LoguercioLeite C.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1304
Subject(s) - cytopathic effect , toxicity , clone (java method) , rabies virus , titer , biology , virus , cytotoxic t cell , rabies , microbiology and biotechnology , pharmacology , virology , chemistry , in vitro , biochemistry , dna , organic chemistry
This work describes the cytopathic effect on cells, cytotoxic action on mice, and antiviral activity of cinnabarin. This substance had no effect on mouse neuroblastoma cells (NA cell, ATCC clone C‐1300) at a concentration of 0.31 mg/ml, it was not able to cause toxic effects in mice at concentrations of 1000 mg/kg, and reduced by four times the titers of the rabies virus at concentrations of 0.31 mg/ml. Copyright © 2003 John Wiley & Sons, Ltd.