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Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa
Author(s) -
Mosaddik M. Ashik,
Haque M. Ekramul
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1303
Subject(s) - antimicrobial , cytotoxicity , bacillus cereus , antibacterial activity , minimum inhibitory concentration , gram positive bacteria , microbiology and biotechnology , gram negative bacteria , shigella , gallic acid , chemistry , bacteria , antibacterial agent , biology , traditional medicine , in vitro , escherichia coli , antibiotics , biochemistry , medicine , antioxidant , salmonella , genetics , gene
The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC 50 values (5.03 µg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and signicant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 µg/mL. Copyright © 2003 John Wiley & Sons, Ltd.