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Pro‐healing effect of Cinnamomum zeylanicum bark
Author(s) -
Kamath Jagadish V.,
Rana A. C.,
Roy Chowdhury Anirban
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1293
Subject(s) - cinnamomum zeylanicum , hydroxyproline , wound healing , breaking strength , bark (sound) , medicine , traditional medicine , phytotherapy , granulation tissue , cinnamomum , surgery , biology , botany , pathology , composite material , ecology , materials science , alternative medicine , essential oil , traditional chinese medicine , cassia
The ethanol extract of the bark of Cinnamomum zeylanicum was evaluated for wound healing activity in Wistar rats. The extract was administered by the oral route at a dose of 250 mg/kg and 500 mg/kg body weight (1/8 and 1/4 of LD 50 , respectively) for all the wound models selected, excision, incision and dead space wounds. The extract signicantly enhanced the wound breaking strength in the case of incision wound, the rate of wound contraction and the period of epithelization in the case of excision wound. The granulation tissue weight, its breaking strength and its hydroxyproline content was also increased by the extract in the dead space wound. Copyright © 2003 John Wiley & Sons, Ltd.