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Antinociceptive activity of Sempervivum tectorum L. extract in rats
Author(s) -
Kekesi Gabriella,
Dobos Ildiko,
Benedek György,
Horvath Gyöngyi
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1288
Subject(s) - nociception , pharmacology , carrageenan , medicine , hyperalgesia , intraperitoneal injection , anesthesia , traditional medicine , receptor
The extract of Sempervivum tectorum L. (Crassulaceae) containing several avonoids is widely used as an antiinammatory agent in folk medicine. Previous studies have demonstrated that various avonoids or avonoid‐containing plant extracts produce signicant antinociception, but no data are available concerning their antinociceptive effect especially at the spinal level. The purpose of the present study was to investigate the antinociceptive activity of Sempervivum tectorum L. extract on acute and inammatory pain sensitivity in awake rats. The pain sensitivity was assessed by the acute tail‐ick test in intact rats and by the paw withdrawal test after carrageenan‐induced inammation using heat stimulus. The plant extract was administered intraperitoneally and intrathecally in rats. The intraperitoneal injection of a high dose of the extract (1000 mg/kg) signicantly ( p < 0.05) increased the paw withdrawal latency of the inamed paw. The intrathecal administration (30–300 µg) caused a small, but signicant increase (10%–15%) in tail‐ick latency. In the carrageenan‐induced inammatory model, the intrathecally applied extract (30–1000 µg) signicantly decreased, but did not relieve the thermal hyperalgesia. The results suggest that the spinal cord does not seem to play an important role in the antinociceptive effects of this plant extract. Copyright © 2003 John Wiley & Sons, Ltd.