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Protective effect of Astragalus corniculatus saponins against myeloid graffi tumour in hamsters
Author(s) -
Krasteva I. N.,
Toshkova R. A.,
Nikolov S. D.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1277
Subject(s) - in vivo , myeloid , biology , myeloid cells , pharmacology , medicine , cancer research , immunology , microbiology and biotechnology
A puried mixture containing mostly saponins (PMS) from Astragalus corniculatus Bieb. was used in an in vivo model to demonstrate its protective effect against myeloid Graf tumour in hamsters. Survivability, tumour growth and tumour transplantability were followed. Comparative studies revealed that the intraperitoneal administration of PMS: (i) decreased the tumour transplantability; (ii) inhibited tumour growth in the early stages of tumour progression; (iii) increased the mean survival time; (iv) reduced the percentage mortality. These results suggest that appropriate use of PMS could outline a promising strategy for the treatment of myeloid Graf tumour. Copyright © 2004 John Wiley & Sons, Ltd.