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Hepatoprotective effect of New Livfit®, a polyherbal formulation, is mediated through its free radical scavenging activity
Author(s) -
Gupta Y. K.,
Sharma Monisha,
Chaudhary Geeta,
Katiyar C. K.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1272
Subject(s) - pyrogallol , lipid peroxidation , chemistry , pharmacology , oral administration , liver toxicity , traditional medicine , pharmacognosy , toxicity , antioxidant , scavenging , biochemistry , medicine , biological activity , in vitro , organic chemistry
The effect of New Livt®, a polyherbal formulation, was studied on pyrogallol‐induced hepatotoxicity in rats. Administration of pyrogallol 100 mg/kg, i.p. caused a signicant increase in liver enzymes as well as a signicant increase in lipid peroxidation. Simultaneous administration of oral New Livt® and pyrogallol prevented these changes in hepatic damage. The results of the study showed that New Livt® exerted a hepatoprotective effect against pyrogallol induced liver toxicity, which was mediated through its free radical scavenging property. Copyright © 2004 John Wiley & Sons, Ltd.