Premium
The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride‐induced hepatotoxicity in rats
Author(s) -
Türkdoğan M. K.,
Ozbek H.,
Yener Z.,
Tuncer I.,
Uygan I.,
Ceylan E.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1266
Subject(s) - carbon tetrachloride , nigella sativa , ccl4 , urtica dioica , cirrhosis , hepatic fibrosis , decoction , pathology , necrosis , coagulative necrosis , fibrosis , traditional medicine , medicine , biology , chemistry , organic chemistry
The role of Nigella sativa L. (Ranunculaceae) (NS) and Urtica dioica L. was investigated (UD) in the prevention of carbon tetrachloride (CCl 4 ) induced liver brosis and cirrhosis. Fifty Sprague‐Dawley rats were allocated into ve groups (I, IIA and B, IIIA and B) and CCl 4 was injected biweekly to all groups. Group I (control, CCl 4 only), group IIA and B (NS xed oil and volatile oil), group IIIA and B (UD xed oil and UD decoction extract) rats were killed at the end of week 12 and histopathological and immunohistochemical examinations of liver tissues were performed. In the control group, coagulation necrosis and hydropic degeneration were marked in the periacinar regions (zone 3) associated with brosis in the periacinar regions and in the portal tracts. In groups IIA–B and IIIA–B (NS and UD), none of the serious histopathological ndings were detected except for sparse coagulation necrosis in the periacinar regions. ASMA‐positive perisinusoidal cells with myobroblastic transformation and lysosomal enzyme activity suggesting brogenesis were also signicantly more common in the control group than in the NS and UD groups. UD and NS seem to be signicantly effective in the prevention of carbon tetrachloride induced hepatotoxicity in rats. Copyright © 2003 John Wiley & Sons, Ltd.