Antitussive activity of  Abies webbiana  Lindl. leaf extract against sulphur dioxide‐induced cough reﬂex in mice | Zendy

Nayak S. S. | Zendy; Ghosh A. K. | Zendy; Srikanth K. | Zendy; Debnath B. | Zendy; Jha T. | Zendy

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Antitussive activity of Abies webbiana Lindl. leaf extract against sulphur dioxide‐induced cough reﬂex in mice

Author(s) -

Nayak S. S.,

Ghosh A. K.,

Srikanth K.,

Debnath B.,

Jha T.

Publication year - 2003

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1263

Subject(s) - codeine , chemistry , traditional medicine , pharmacology , positive control , medicine , morphine

The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited signicant antitussive activity compared with the control in a dose dependent manner. The antitussive activity of the extract was compared with that of codeine phosphate, a prototype antitussive agent. The A. webbiana leaf extract (400 and 600 mg/kg) showed maximum inhibition of cough frequency by 71.69% and 78.67%, respectively, when compared with the control group and was comparable in effect to codeine phosphate. Copyright © 2003 John Wiley & Sons, Ltd.

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