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Antitussive activity of Abies webbiana Lindl. leaf extract against sulphur dioxide‐induced cough reflex in mice
Author(s) -
Nayak S. S.,
Ghosh A. K.,
Srikanth K.,
Debnath B.,
Jha T.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1263
Subject(s) - codeine , chemistry , traditional medicine , pharmacology , positive control , medicine , morphine
The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited signicant antitussive activity compared with the control in a dose dependent manner. The antitussive activity of the extract was compared with that of codeine phosphate, a prototype antitussive agent. The A. webbiana leaf extract (400 and 600 mg/kg) showed maximum inhibition of cough frequency by 71.69% and 78.67%, respectively, when compared with the control group and was comparable in effect to codeine phosphate. Copyright © 2003 John Wiley & Sons, Ltd.