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Inhibition of angiotensin converting enzyme by lithospermic acid B isolated from radix Salviae miltiorrhiza Bunge
Author(s) -
Kang Dae Gill,
Oh Hyuncheol,
Chung Hun Taeg,
Lee Ho Sub
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1250
Subject(s) - salvia miltiorrhiza , angiotensin converting enzyme , pharmacology , renin–angiotensin system , ic50 , enzyme inhibitor , angiotensin ii , traditional medicine , pharmacognosy , radix (gastropod) , ace inhibitor , medicine , enzyme , chemistry , biological activity , biology , in vitro , biochemistry , endocrinology , traditional chinese medicine , blood pressure , alternative medicine , pathology , botany
The roots of Salviae miltiorrhiza (RSM) have been traditionally used for treatment of hypertensive disease in China, Korea, and Japan. Bioassay guided fractionation and purication as assayed by angiotensin converting enzyme (ACE) inhibitory assay resulted in the isolation of lithospermic acid B (LSB) as an active principle. The ACE plasma activities were signicantly inhibited by the addition of LSB in a dose‐dependent manner of which IC 50 value was 86 µg/ml (120 µM). Moreover, angiotensin I‐induced contraction was markedly attenuated by prior exposure of endothelium‐intact aortic rings to LSB. These results suggest that RSM‐induced antihypertensive effect may be, at least in part, due to ACE inhibitory effect of LSB. Copyright © 2003 John Wiley & Sons, Ltd.