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Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves
Author(s) -
Badami Shrishailappa,
Manohara Reddy S. A.,
Kumar E. P.,
Vijayan P.,
Suresh B.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1229
Subject(s) - alkaloid , pharmacognosy , in vivo , toxicity , pharmacology , biology , biological activity , chemistry , traditional medicine , in vitro , botany , medicine , biochemistry , microbiology and biotechnology
The total alkaloid fraction of the methanolic extract of Solanum pseudocapsicum leaves was tested for its in‐vivo antitumor activity against Dalton's Lymphoma Ascites model in mice. The total alkaloid fraction at 2.5 and 5.0 mg/kg body weight doses exhibited antitumor activity as revealed by the signicant increase in the mean survival time and the percentage increase in life span of tumor bearing mice. The antitumor activity observed may be due to its cytotoxic properties. However the treatment caused a signicant decrease in the body weight below the normal indicating the toxicity of the treatment. Copyright © 2003 John Wiley & Sons, Ltd.