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Pharmacological effects of extracts from Valeriana adscendens Trel. II. Effects on GABA uptake and amino acids
Author(s) -
De Feo Vincenzo,
Faro Carlos
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1225
Subject(s) - neurotransmitter , chemistry , pharmacognosy , pharmacology , amino acid , gamma aminobutyric acid , aqueous extract , biochemistry , biological activity , traditional medicine , biology , in vitro , medicine , receptor
Methanolic and aqueous extracts from Valeriana adscendens (Valerianaceae), that previously demonstrated neuroleptic‐like properties, were studied for their effects on GABA uptake and amino acid neurotransmitter levels. The methanolic estract showed a significant effect in inhibiting GABA uptake and in decreasing the intracellular content of amino acid neurotransmitters in crude synaptosomes of rat. The data obtained could explain the neuroleptic activity of methanolic extract of the plant and confirm its traditional use. Copyright © 2003 John Wiley & Sons, Ltd.