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Lignans from Acanthopanax chiisanensis having an inhibitory activity on prostaglandin E 2 production
Author(s) -
Lee Sanghyun,
Ban Hyun Seung,
Kim Yong Pil,
Kim BakKwang,
Cho Seon Haeng,
Ohuchi Kazuo,
Shin Kuk Hyun
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1220
Subject(s) - sesamin , lignan , araliaceae , chemistry , chloroform , pharmacognosy , prostaglandin , potency , inhibitory postsynaptic potential , biological activity , prostaglandin e2 , stereochemistry , traditional medicine , pharmacology , in vitro , biochemistry , biology , medicine , chromatography , endocrinology , food science , alternative medicine , pathology , ginseng
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited the significant inhibition of TPA‐induced prostaglandin E 2 (PGE 2 ) production in rat peritoneal macrophages. Five lignans were isolated from the chloroform fraction and their structures were elucidated as l ‐sesamin, helioxanthin, savinin, taiwanin C, and 3‐(3,4‐dimethoxybenzyl)‐2‐(3,4‐methylenedioxybenzyl)butyrolactone. Among the lignans tested, taiwanin C showed the most potent inhibitory activity (IC 50 = 0.12 µM) on PGE 2 production with the relative order of potency, taiwanin C ≫ 3‐(3,4‐dimethoxybenzyl)‐2‐(3,4‐methylenedioxybenzyl)butyrolactone > savinin = helioxanthin. l ‐Sesamin showed no inhibitory activity at 30 µM. Copyright © 2005 John Wiley & Sons, Ltd.
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