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Alkaloids from Brugmansia arborea (L.) Lagerhein reduce morphine withdrawal in vitro
Author(s) -
Capasso Anna,
de Feo Vincenzo
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1218
Subject(s) - tropane , solanaceae , traditional medicine , medicinal plants , morphine , alkaloid , pharmacognosy , phytotherapy , atropa belladonna , biology , botany , in vitro , medicine , pharmacology , biological activity , biochemistry , alternative medicine , pathology , neuroscience , gene
Traditional medicine is a primary source for the study of medicinal plants. In some countries, knowledge about the therapeutic use of medicinal plants is very deep and very often ‘magical’ plants also are used to diagnose and treat illnesses. The study of these plants can help in the research of metabolites active on the central and peripheral nervous system. Brugmansia arborea (L.) Lagerheim (Solanaceae) is used in the northern Peruvian Andes for magic–therapeutic purposes and the present study examined the effect of three pure tropane alkaloids from Brugmansia arborea (L.) Lagerhein (Solanaceae) on morphine withdrawal in vitro . All the tropane alkaloids isolated from Brugmansia arborea (L.) (10 −7 , 5 × 10 −7 , 10 −6 m ) signicantly and in a concentration dependent manner reduced morphine withdrawal. The results of the present study suggest that these alkaloids may be a potential anti‐additive agent. Copyright © 2003 John Wiley & Sons, Ltd.