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Protective effects of saffron ( Crocus sativus Linn.) on genotoxins‐induced oxidative stress in Swiss albino mice
Author(s) -
Premkumar K.,
Abraham Suresh K.,
Santhiya S. T.,
Ramesh A.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1209
Subject(s) - crocus sativus , lipid peroxidation , oxidative stress , antioxidant , glutathione , pharmacology , chemistry , safranal , crocus , traditional medicine , biochemistry , medicine , enzyme
The modifying effects of the aqueous extract of saffron (dried stigmas of Crocus sativus Linn.) on cisplatin (CIS), cyclophosphamide (CPH), mitomycin‐C (MMC) and urethane (URE) induced alterations in lipid peroxidation and antioxidant status were investigated in Swiss albino mice. Three doses of saffron (20, 40 and 80 mg/kg body weight) were orally administered to mice for 5 consecutive days prior to administration of genotoxins. A signicant reduction in the extent of lipid peroxidation with a concomitant increase in the liver enzymatic (SOD, CAT, GST, GPx) and non‐enzymatic antioxidants (reduced glutathione) were observed in saffron pretreated animals compared with the genotoxins alone treated animals. However, the modulatory effects were not always dose dependent. Our data suggest that saffron may exert its chemopreventive effects by modulation of lipid peroxidation, antioxidants and detoxication systems. Copyright © 2003 John Wiley & Sons, Ltd.