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Analgesic and anti‐inflammatory activity of the leaf essential oil of Laurus nobilis Linn.
Author(s) -
Sayyah M.,
Saroukhani G.,
Peirovi A.,
Kamalinejad M.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1197
Subject(s) - laurus nobilis , analgesic , lauraceae , essential oil , traditional medicine , anti inflammatory , medicine , pharmacology , muscle relaxant , sedative , piroxicam , nociception , pharmacognosy , morphine , chemistry , biological activity , biology , botany , food science , biochemistry , alternative medicine , pathology , in vitro , receptor
The leaf essential oil of Laurus nobilis Linn. (Lauraceae) has been evaluated for antinociceptive and anti‐inammatory activities in mice and rats. The essential oil exhibited: (1) a signicant analgesic effect in tail‐ick and formalin tests; (2) a dose‐dependent anti‐inammatory effect in the formalin‐induced edema and (3) a moderate sedative effect at the anti‐inammatory doses. The analgesic and anti‐inammatory effect of the essential oil was comparable to reference analgesics and non‐steroid anti‐inammatory drugs: morphine and piroxicam. Present results make the essential oil worthy of further investigations. Copyright © 2003 John Wiley & Sons, Ltd.