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Effect of Choto‐san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM)
Author(s) -
Mizushima Yutaka,
Kan Shin,
Yoshida Satoshi,
Irie Yoshifumi,
Urata Yukitomo
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1193
Subject(s) - kampo , senescence , medicine , memory impairment , memory retention , traditional medicine , psychology , neuroscience , pathology , psychiatry , cognition , alternative medicine
Effect of Choto‐san (TJ–47), a Kampo medicine, on impairment of learning performance was evaluated by means of a step‐through passive avoidance task in SAMP8 mice, a senescence‐prone substrain. Tokishakuyaku‐san (TJ–23), another Kampo medicine, was also employed for comparison. SAMP8 mice at the age of 10–12 months showed a poorer passive avoidance response than SAMR1 mice, a senescence‐resistant substrain, in the memory‐retention test, but not in the memory‐acquisition test. Improved response in the memory‐retention test was observed in SAMP8 mice treated with TJ–47, and almost equal degree of improvement was also observed after treatment with TJ–23. These results suggest that a long‐term administration of Choto‐san could improve to some extent the impairment of memory caused by aging. Copyright © 2003 John Wiley & Sons, Ltd.