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Antiprotozoal activity of the constituents of Teloxys graveolens
Author(s) -
Calzada Fernando,
Velázquez Claudia,
CedilloRivera Roberto,
Esquivel Baldomero
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1192
Subject(s) - antiprotozoal , traditional medicine , pharmacognosy , medicine , biology , biological activity , in vitro , biochemistry
Antiprotozoal activity‐guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC 50 12.5 and 16.8 µg/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC 50 17.2 µg/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases. Copyright © 2003 John Wiley & Sons, Ltd.