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Adaptogenic activity of a novel withanolide‐free aqueous fraction from the roots of Withania somnifera Dun. (Part II)
Author(s) -
Singh B.,
Chandan B. K.,
Gupta D. K.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1189
Subject(s) - withania somnifera , withanolide , traditional medicine , pharmacognosy , aqueous extract , aqueous solution , fraction (chemistry) , chemistry , medicine , pharmacology , in vitro , biological activity , biochemistry , chromatography , organic chemistry , pathology , alternative medicine
In the Indian traditional system of medicine Withania somnifera Dun. is widely regarded as the Indian Ginseng. A new withanolide‐free hydrosoluble fraction was isolated from the roots of Withania somnifera Dun. and was evaluated for putative antistress activity against a battery of tests to delineate the activity of this fraction. The latter fraction exhibited signicant antistress activity in a dose‐related manner (Singh et al. , 2001) and was further studied against chemical and physical induced stress in rats and mice. The extract of Withania somnifera root (a commercial preparation available locally) was also used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety with a high therapeutic index. Copyright © 2003 John Wiley & Sons, Ltd.