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A hot water extract of Chlorella pyrenoidosa reduces body weight and serum lipids in ovariectomized rats
Author(s) -
Hidaka Saburo,
Okamoto Yoshizo,
Arita Masaki
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1178
Subject(s) - ovariectomized rat , endocrinology , medicine , chlorella pyrenoidosa , triglyceride , chemistry , bone mineral , blood lipids , body weight , lipid metabolism , chlorella , cholesterol , biology , hormone , osteoporosis , botany , algae
The effects of a hot water extract of Chlorella pyrenoidosa , which contains chlorella growth factor (CGF), on the body weight, serum lipids, and the bone mass were evaluated using an ovariectomized rat as a model for postmenopausal bone loss. Rats were divided into four groups: sham‐operated (Sham), Sham given the CGF solution, ovariectomized (OVX), and OVX given the CGF solution, respectively. Administration of the extract to OVX rats suppressed the body weight gain. After 7 weeks, the administration of the extract to the OVX group reduced increases in both serum total cholesterols and high‐density lipoprotein (HDL) cholesterols. It also normalized the decrease of triglyceride level in the OVX group. The ovariectomy decreased the tibial bone mineral density (BMD) by 19%, and the administration of the extract to OVX rats did not inhibit this decrease. These results suggest that a dietary supplement of CGF may be useful to control the body weight and improve lipid metabolism of menopausal women. Copyright © 2004 John Wiley & Sons, Ltd.