Screening of 25 compounds isolated from  Phyllanthus  species for anti‐human hepatitis B virus  in vitro | Zendy

Huang RayLing | Zendy; Huang YuLing | Zendy; Ou JunChih | Zendy; Chen ChienChih | Zendy; Hsu FengLin | Zendy; Chang Chungming | Zendy

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Screening of 25 compounds isolated from Phyllanthus species for anti‐human hepatitis B virus in vitro

Author(s) -

Huang RayLing,

Huang YuLing,

Ou JunChih,

Chen ChienChih,

Hsu FengLin,

Chang Chungming

Publication year - 2003

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1167

Subject(s) - phyllanthus , hbeag , hbsag , traditional medicine , euphorbiaceae , in vitro , biology , virology , pharmacognosy , virus , hepatitis b virus , medicine , biological activity , botany , biochemistry

Using an HBV‐producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin ( 1 ), nirtetralin ( 3 ), hinokinin ( 5 ) and geraniin ( 13 ) at the non‐cytotoxic concentration of 50 µ m , suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin ( 1 ) showed the best anti‐HBsAg activity, while the most potent anti‐HBeAg activity was observed with hinokinin ( 5 ). Copyright © 2003 John Wiley & Sons, Ltd.

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