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In vitro antagonistic activity of monoterpenes and their mixtures against ‘toe nail fungus’ pathogens
Author(s) -
Ramsewak Russel S.,
Nair Muraleedharan G.,
Stommel Manfred,
Selanders Louise
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1164
Subject(s) - thymol , camphor , eucalyptus oil , trichophyton , menthol , essential oil , traditional medicine , epidermophyton floccosum , trichophyton rubrum , microsporum , microbiology and biotechnology , fungus , turpentine , eucalyptol , microsporum canis , terpene , chemistry , food science , biology , botany , medicine , organic chemistry , antifungal , immunology
The antibiotic effect of the active ingredients in Meijer™ medicated chest rub (eucalyptus oil, camphor and menthol) as well as the inactive ingredients (thymol, oil of turpentine, oil of nutmeg and oil of cedar leaf) were studied in vitro using the fungal pathogens responsible for onychomycosis, such as the dermatophytes Tricophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Epidermophyton occosum and Epidermophyton stockdale . The zones of inhibition data revealed that camphor (1), menthol (2), thymol (3) and oil of Eucalyptus citriodora were the most efcacious components against the test organisms. The MIC 100 for mixtures of these four components in various carrier solvents revealed that formulations consisting of 5 mg/mL concentrations of each have a potential to be efffective in controlling onychomycosis. Copyright © 2003 John Wiley & Sons, Ltd.