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Acaricidal activity of Uvaria Versicolor and Uvaria Klaineana (Annonaceae)
Author(s) -
Akendengue B.,
NgouMilama E.,
BourobouBourobou H.,
Essouma J.,
Roblot F.,
Gleye C.,
Laurens A.,
Hocquemiller R.,
Loiseau P.,
Bories C.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1158
Subject(s) - annonaceae , benzyl benzoate , dichloromethane , chemistry , pharmacognosy , traditional medicine , hexane , chromatography , in vitro , organic chemistry , medicine , biological activity , solvent , biochemistry
Three Uvaria species, namely U. klaineana , U. mocoli and U. versicolor were tested in vitro against Dermatophagoides pteronyssinus , the European house dust mite. The most active extracts were the Uvaria versicolor stems crude methanol and hexane extracts with EC 50 values of 0.095 g/m 2 and 0.12 g/m 2 , respectively. The bioassay‐guided fractionation of the hexane extract led to the isolation of benzyl benzoate (1) which exhibited an EC 50 value of 0.045 g/m 2 . A new avanone, versuvanone (2), and the known oxoaporphine liriodenine (3) were also isolated from this species and showed EC 50 values > 1.5 g/m 2 . A weak acaricidal activity (0.85 g/m 2 ) was observed for the dichloromethane extract of Uvaria klaineana , due to the presence of benzyl benzoate. Uvaria mocoli was inactive. The structures of compounds were elucidated using 2D‐NMR techniques. Copyright © 2003 John Wiley & Sons, Ltd.
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