Korean medicinal plants inhibiting to Human Immunodeﬁciency Virus type 1 (HIV‐1) fusion | Zendy

Chang YoungSu | Zendy; Woo EunRhan | Zendy

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Korean medicinal plants inhibiting to Human Immunodeﬁciency Virus type 1 (HIV‐1) fusion

Author(s) -

Chang YoungSu,

Woo EunRhan

Publication year - 2003

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1155

Subject(s) - syncytium , cell fusion , traditional medicine , glycoprotein , pharmacognosy , virus , human immunodeficiency virus (hiv) , bark (sound) , enfuvirtide , biology , virology , in vitro , chemistry , botany , biological activity , biochemistry , gp41 , medicine , cell , immunology , antibody , ecology , epitope

In order to nd novel anti‐HIV agents from natural products, 80 MeOH extracts of Korean plants were applied to a syncytia formation inhibition assay, which is based on the interaction between the HIV‐1 envelope glycoprotein gp120/41 and the cellular membrane protein CD4 of T lymphocytes. The most potent HIV‐1 fusion inhibition was shown by the stem bark of Ailanthus altissima with 74.9 ± 4.4% at a concentration of 100 µg/mL. Copyright © 2003 John Wiley & Sons, Ltd.

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