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Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation
Author(s) -
Damre A. A,
Damre A. S.,
Saraf M. N.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1152
Subject(s) - sesquiterpene lactone , alkaline phosphatase , sesquiterpene , chemistry , lactone , acid phosphatase , pellet , dry weight , biochemistry , enzyme , biology , botany , stereochemistry , zoology
The sesquiterpene lactone fraction of Saussurea lappa roots was evaluated for its effect on the transudative, exudative and proliferative phases of inammation using the cotton pellet granuloma assay in rats. The fraction (25–100 mg/kg, p.o.) showed signicant dose‐dependent inhibition of the increase in wet weight of the cotton pellet at 3 h (transudative phase), leakage of dye from the bloodstream around granuloma at 24 h (exudative phase) and increase in dry weight of the cotton pellet on day 6 (proliferative phase). It signicantly lowered the elevated biochemical parameters such as alkaline phosphatase, acid phosphatase, γ ‐glutamyltranspeptidase and signicantly elevated the lowered albumin concentration in serum. The studies suggest that the antiinammatory activity of the sesquiterpene lactone fraction of S. lappa may, in part, be due to stabilization of lysosomal membranes and an antiproliferative effect. Copyright © 2003 John Wiley & Sons, Ltd.