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Antiasthmatic activity of the methanol extract of leaves of Passiflora incarnata
Author(s) -
Dhawan Kamaldeep,
Kumar Suresh,
Sharma Anupam
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1151
Subject(s) - bronchospasm , agonist , pharmacology , chemistry , acetylcholine , methanol , traditional medicine , medicine , receptor , biochemistry , asthma , organic chemistry
The methanol extract of the leaves of P. incarnata was evaluated for its antiasthmatic effects against acetylcholine chloride (Ach)‐induced‐bronchospasm in guinea‐pigs at doses of 50, 100 and 200 mg/kg. Using a 7‐day treatment regimen, signicant prevention of dyspnoea‐related‐convulsions was noted in the animals treated with a 100 mg/kg dose of this extract. No preventive effect was exhibited by the 50 mg/kg dose and at a higher dose, i.e. 200 mg/kg, the preventive effects against Ach‐chloride‐induced‐dyspnoea were also reduced. This may be due to defective alpha‐adrenoceptor function reported after excessive or continuous administration of an alpha‐receptor agonist. Copyright © 2003 John Wiley & Sons, Ltd.