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Antiprotozoal activity of the constituents of Rubus coriifolius
Author(s) -
Alanís Alma Delia,
Calzada Fernando,
CedilloRivera Roberto,
Meckes Mariana
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1150
Subject(s) - antiprotozoal , ellagic acid , entamoeba histolytica , traditional medicine , gallic acid , biology , phytochemical , metronidazole , pharmacognosy , botany , microbiology and biotechnology , polyphenol , biological activity , biochemistry , medicine , antioxidant , antibiotics , in vitro
Extraction of the aerial parts of Rubus coriifolius , a medicinal plant used by the Maya communities in Southern Mexico to treat bloody diarrhoea, resulted in the isolation of seven known compounds (−)‐epicatechin, (+)‐catechin, hyperin, nigaichigoside F1, β ‐sitosterol 3‐ O ‐ β ‐ d ‐glucopyranoside, gallic acid and ellagic acid. All compounds were tested for their antiprotozoal activity against Entamoeba histolytica and Giardia lambia . Epicatechin was the main responsible for the antiprotozoal activity of the extract against both protozoa, its activity was comparable to emetine, but no exceeded that of metronidazole. Copyright © 2003 John Wiley & Sons, Ltd.