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Protective effects of Acanthopanax Radix extract against endotoxemia induced by lipopolysaccharide
Author(s) -
Yokozawa Takako,
Rhyu Dong Young,
Chen Cui Ping
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1145
Subject(s) - lipid peroxidation , catalase , nitric oxide , pharmacology , glutathione peroxidase , lipopolysaccharide , reactive oxygen species , chemistry , glutathione , antioxidant , kidney , superoxide dismutase , creatinine , biochemistry , endocrinology , medicine , enzyme , organic chemistry
Abstract Endotoxemia causes an enhanced production of reactive oxygen radicals, which contribute to multiple organ dysfunction. When rats were given intravenous lipopolysaccharide and tested 6 h later we found that the activities of catalase and glutathione peroxidase (GSH‐Px) in kidney, were acutely suppressed while in serum the levels of nitric oxide (NO), lipid peroxidation, urea nitrogen and creatinine were signicantly increased, indicating the excessive production of reactive oxygen radicals and the presence of renal injury. Pretreatment of rats with Acanthopanax Radix extract administered orally for 30 days reduced the NO and lipid peroxidation levels, increased the activities of catalase and GSH‐Px, and attenuated the renal dysfunction. These results suggested that scavenging of reactive oxygen radicals is part of the mechanism by which Acanthopanax Radix extract works as an effective agent in preventing multiple organ dysfunction. Copyright © 2003 John Wiley & Sons, Ltd.