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Antiangiogenic activity of lupeol from Bombax ceiba
Author(s) -
You YoungJae,
Nam NguyenHai,
Kim Yong,
Bae KiHwan,
Ahn ByungZun
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1140
Subject(s) - lupeol , traditional medicine , in vitro , umbilical vein , pharmacognosy , biological activity , chemistry , biology , medicine , biochemistry
In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a signicant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity‐guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 µg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK‐MEL‐2, A549, and B16‐F10 melanoma. Copyright © 2003 John Wiley & Sons, Ltd.