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Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats
Author(s) -
Upasani C. D.,
Balaraman R.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1135
Subject(s) - lipid peroxidation , spirulina (dietary supplement) , endogeny , kidney , antioxidant , chemistry , lead acetate , pharmacology , endocrinology , medicine , biology , toxicity , biochemistry , raw material , organic chemistry
The present study aims to investigate the protective effect of Spirulina on lead‐induced changes in the levels of lipid peroxidation and endogenous antioxidants in liver, lung, heart, kidney and brain of rats. Levels of elemental lead were also measured in the organs of rats in all experimental groups. In the liver, lung, heart and kidney of lead‐exposed animals, there was a signicant ( p < 0.001) increase in the lipid peroxidation and a decrease in the levels of endogenous antioxidants. Although, Spirulina did not affect the deposition of lead in organs apart from the brain, simultaneous administration of Spirulina to lead exposed animals signicantly ( p < 0.001) inhibited lipid peroxidation and restored the levels of endogenous antioxidants to normal. To conclude, Spirulina had a signicant effect on scavenging free radicals, thereby protecting the organs from damage caused by the exposure to lead. Further more, Spirulina showed a signicant ( p < 0.05) decrease in the deposition of lead in the brain. Copyright © 2003 John Wiley & Sons, Ltd.