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Effects of Zuccagnia punctata on the gastrointestinal tract in rats and mice
Author(s) -
Ortega C. A.,
María A. O. M.,
Giordano O. S.,
Gianello J. C.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1127
Subject(s) - gastrointestinal tract , fabaceae , pharmacognosy , medicine , phytotherapy , traditional medicine , pharmacology , ethanol , biology , biological activity , in vitro , botany , biochemistry , pathology , alternative medicine
A pharmacological evaluation of Zuccagnia punctata Cav. (Fabaceae) on the gastrointestinal tract was made in rats and mice. 2′,4′‐dihydroxychalcone and 2′,4′‐dihydroxy‐3′‐methoxychalcone were isolated from Zuccagnia punctata . The data reported in the present work indicate that the acetone extract and infusion of Zuccagnia punctata reduced intestinal transit in rats and mice and offered protection against ethanol‐induced ulceration in rats. The Z. punctata effect could be due, in part, to the presence of 2′,4′‐dihydroxychalcone and 2′,4′‐dihydroxy‐3′‐methoxychalcone in this plant. Copyright © 2003 John Wiley & Sons, Ltd.