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Mitigation of thyroxine‐induced hyperglycaemia by two plant extracts
Author(s) -
Tahiliani Pankaj,
Kar Anand
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1121
Subject(s) - medicine , endocrinology , trigonella , thiouracil , hormone , thyroid function , thyroid , bulb , antithyroid agent , triiodothyronine , chemistry , biology , graves' disease , botany , traditional medicine
Extracts of Trigonella foenum‐graecum (TFG) seed and Allium sativum (AS) bulb were evaluated for their efcacy to ameliorate l ‐thyroxine ( l ‐T 4 ) induced hyperglycaemia in rats. Simultaneously, the serum cholesterol concentration, a supporting parameter for thyroid function, was also estimated. Thyroxine treatment in rats (300 µg/kg b. wt./day) increased the levels of both the thyroid hormones, namely thyroxine (T 4 ) and tri‐iodothyronine (T 3 ) with a concomitant elevation in serum glucose concentration and a reduction in serum cholesterol level. Administration of TFG (220 mg/kg/day) and AS (500 mg/kg/day) extracts in hyperthyroid animals decreased the serum glucose concentration as well as the serum thyroid hormones. For comparison, propyl thiouracil (PTU), an antithyroid compound, was used as the standard at a daily dose of 10 mg/kg. The reductions in serum glucose and thyroid hormone concentrations in the plant extract treated groups were comparable to that in PTU treated animals. Our ndings indicate that TFG seed and AS bulb extracts may prove to be effective in the treatment of thyroxine‐induced hyperglycaemia. Copyright © 2003 John Wiley & Sons, Ltd.