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In vitro cytotoxicity activity of diosquinone, a naphthoquinone epoxide
Author(s) -
Adeniyi B. A.,
Robert M. F.,
Chai H.,
Fong H. H. S.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1116
Subject(s) - cytotoxicity , traditional medicine , antibacterial activity , cell culture , pharmacognosy , lncap , in vitro , bark (sound) , biological activity , biology , chemistry , cancer cell , biochemistry , cancer , medicine , bacteria , genetics , ecology
Diosquinone [1], a naphthoquinone epoxide previously isolated from the root bark of Diospyros mespiliformis (Hostch) and D. tricolor [Ebenaceae] is been assessed for cytotoxicity activity against ten cancer cell lines by standard NIH method. The ethno‐pharmacological claim of this plant and the previously observed good antibacterial activity of this compound among the others isolated from this plant suggest its probable cytotoxicity activity. Diosquinone was observed to be very active against most of the cancer cell lines. It shows very good activity against all the cell lines tested with ED 50 value ranging between 0.18 µg/ml. against Human Glioblastoma (U373) to 4.5 µg/ml. against Hormone dependent human prostrate cancer( LNCaP). Copyright © 2003 John Wiley & Sons, Ltd.