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The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia‐induced lethality in mice
Author(s) -
Hosseinzadeh Hossein,
Sadati Nargess
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1114
Subject(s) - lethality , allium sativum , traditional medicine , chemistry , pharmacognosy , aqueous extract , sativum , hypoxia (environmental) , pharmacology , toxicology , biology , biological activity , botany , medicine , biochemistry , oxygen , in vitro , organic chemistry
The antihypoxic activity of Allium sativum clove (garlic) aqueous and methanolic extracts was studied in mice. The extracts of garlic showed that the antihypoxic effect was dose‐dependent. The minimum effective doses of aqueous and methanolic extracts were 0.2 g/kg and 5.12 g/kg, respectively. Phenytoin, 50 mg/kg, and R‐phenylisopropyladenosine (R‐PIA), 1.6 mg/kg (R‐PIA) as positive controls increased survival time up to 52.5 ± 2.9 min and 120.5 ± 6 min, respectively, compared to normal saline (34.73 ± 0.71 min). The high doses of aqueous (16.9 g/kg) and methanolic (12.8 g/kg) extracts increased survival time up to 73.17 ± 4.9 and 68.41 ± 3.7, respectively. These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia‐induced lethality in mice. Copyright © 2003 John Wiley & Sons, Ltd.