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Correction of the high blood viscosity syndrome by a mixture of diquertin and ascorbic acid in vitro and in vivo
Author(s) -
Plotnikov M. B.,
Aliev O. I.,
Maslov M. Ju.,
Vasiliev A. S.,
Tjukavki. A.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1113
Subject(s) - ascorbic acid , blood viscosity , in vivo , viscosity , rheology , chemistry , pharmacology , medicine , food science , materials science , biology , microbiology and biotechnology , composite material
Abstract Diquertin was shown to diminish blood viscosity, to decrease the aggregation of erythrocytes, and to increase their deformability using a model of the high blood viscosity syndrome in vitro . A mixture of Diquertin with Ascorbic Acid was more effective in improving rheological indicators of blood, then either Diquertin or Tanakan. On a model of chronic brain ischemia, which is accompanied by signicant deterioration of the rheological properties of blood, it was shown that a therapy with a mixture of Diquertin and Ascorbic Acid decreases the expression of the high blood viscosity syndrome. Copyright © 2003 John Wiley & Sons, Ltd.