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Activity of Zanthoxylum clava‐herculis extracts against multi‐drug resistant methicillin‐resistant Staphylococcus aureus (mdr‐MRSA)
Author(s) -
Gibbons Simon,
Leimkugel Julia,
Oluwatuyi Moyo,
Heinrich Michael
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1112
Subject(s) - chelerythrine , sanguinarine , staphylococcus aureus , alkaloid , methicillin resistant staphylococcus aureus , phenanthridine , antibiotics , microbiology and biotechnology , biology , traditional medicine , chemistry , medicine , bacteria , stereochemistry , botany , biochemistry , genetics , protein kinase c , enzyme
In a continuing search for compounds with antibiotic activity against methicillin‐resistant Staphylococcus aureus (MRSA) possessing multidrug efux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava‐herculis . Bioassay‐guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efux mechanisms. Copyright © 2003 John Wiley & Sons, Ltd.