Activity of  Zanthoxylum clava‐herculis  extracts against multi‐drug resistant methicillin‐resistant  Staphylococcus aureus  (mdr‐MRSA) | Zendy

Gibbons Simon | Zendy; Leimkugel Julia | Zendy; Oluwatuyi Moyo | Zendy; Heinrich Michael | Zendy

Premium

Activity of Zanthoxylum clava‐herculis extracts against multi‐drug resistant methicillin‐resistant Staphylococcus aureus (mdr‐MRSA)

Author(s) -

Gibbons Simon,

Leimkugel Julia,

Oluwatuyi Moyo,

Heinrich Michael

Publication year - 2003

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1112

Subject(s) - chelerythrine , sanguinarine , staphylococcus aureus , alkaloid , methicillin resistant staphylococcus aureus , phenanthridine , antibiotics , microbiology and biotechnology , biology , traditional medicine , chemistry , medicine , bacteria , stereochemistry , botany , biochemistry , genetics , protein kinase c , enzyme

In a continuing search for compounds with antibiotic activity against methicillin‐resistant Staphylococcus aureus (MRSA) possessing multidrug efux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava‐herculis . Bioassay‐guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efux mechanisms. Copyright © 2003 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research