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Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model
Author(s) -
Kasahara Yoshimasa,
Yasukawa Ken,
Kitanaka Susumu,
Khan M. Taufiq,
Evans Fred J.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1099
Subject(s) - tagetes patula , inflammation , bradykinin , histamine , pharmacology , carrageenan , granulation tissue , vascular permeability , serotonin , medicine , chemistry , traditional medicine , endocrinology , biology , biochemistry , immunology , botany , wound healing , receptor
The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E 1 , but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. Copyright © 2002 John Wiley & Sons, Ltd.