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Evaluation of anti‐inflammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats
Author(s) -
Mandal Subhash C.,
Mohana Lakshmi S.,
Ashok Kumar C. K.,
Sur Tapas K.,
Boominathan R.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1095
Subject(s) - rubiaceae , histamine , traditional medicine , pharmacology , pellet , drug , chemistry , biology , medicine , botany , zoology
Abstract The anti‐inammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inammation such as carragenin, histamine and dextran induced pedal inammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively; when compared to that of control animals. The effect was comparable with that of the standard drug indomethacin, a standard non‐steroidal anti‐inammatory drug. Simultaneous subplantar administration of the extract and carrageenin in a mixture helps in differentiating true anti‐inammatory action from an apparent anti‐inammatory effect due to counter‐irritant activity. The methanol extract also effectively and signicantly reduced cotton pellet induced granuloma. The percentage of inhibition was 62.78 at the dose 500 mg/kg, thereby suggesting its activity in the proliferative phase of the inammatory process. Copyright © 2003 John Wiley & Sons, Ltd.