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Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid
Author(s) -
Plotnikov M. B.,
Aliev O. I.,
Maslov M. Ju,
Vasiliev A. S.,
Tjukavki. A.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1082
Subject(s) - ascorbic acid , blood viscosity , fibrinogen , plasma viscosity , myocardial infarction , erythrocyte deformability , hemorheology , medicine , whole blood , viscosity , chemistry , cardiology , red blood cell , biochemistry , food science , materials science , composite material
In a model of the high blood viscosity syndrome, developed after myocardial infarction in rats, it was observed that a therapy of a combination of diquertin (20 mg/kg) and ascorbic acid (50 mg/kg) for a period of 6 days, resulted in an improvement of haemorheological indices. The decrease in blood viscosity was primarily due to an improved deformability of erythrocytes, and to some extent, due to a decrease in the content of plasma fibrinogen and erythrocyte aggregation. Copyright © 2003 John Wiley & Sons, Ltd.