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Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice
Author(s) -
Hosseinzadeh H.,
Ramezani M.,
Danaei A. R.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1020
Subject(s) - alloxan , glibenclamide , medicine , acute toxicity , maceration (sewage) , phytochemical , toxicity , diabetes mellitus , sulfonylurea , ethanol , blood sugar , pharmacology , oral administration , traditional medicine , endocrinology , chemistry , biochemistry , materials science , composite material
The antihyperglycaemic activity of a Securigera securidaca aqueous infusion and an ethanol maceration extract of seeds was studied in normoglycaemic, glucose‐induced hyperglycaemic and alloxan‐induced diabetic mice. The acute toxicity of the ethanol extract was more than that of the aqueous one. The phytochemical analysis showed that the seed extracts were rich in flavonoids. The intraperitoneal and oral administration of the aqueous and ethanol extracts significantly reduced blood glucose in alloxan‐induced diabetic mice. In normoglycaemic and glucose‐induced hyperglycaemic mice, the blood glucose levels were not significantly different from the control. Glibenclamide was not able to lower blood glucose in alloxan‐induced diabetic mice, while it significantly lowered the blood sugar in normoglycaemic mice. The results indicate that S. securidaca seed extracts significantly reduce blood glucose in alloxan‐induced diabetic mice by a mechanism different from that of sulfonylurea agents. Copyright © 2002 John Wiley & Sons, Ltd.