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Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract
Author(s) -
Mukherjee Kakali,
Saha B. P.,
Mukherjee Pulok K.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1013
Subject(s) - antipyretic , traditional medicine , rectal temperature , leucas , medicine , yeast , pharmacognosy , phytotherapy , analgesic , pharmacology , chemistry , biology , biological activity , anesthesia , in vitro , biochemistry , alternative medicine , pathology , fishery
Methanol extract of Leucas lavandulaefolia (LLFE) was subjected to antipyretic evaluation with yeast‐induced pyrexia in rats. A yeast suspension (10 mL/kg, s.c.) increased the rectal temperature 19 h after administration. The extract at doses of 100, 200, 400 mg/kg (i.p.) produced significant dose dependent lowering of body temperature in yeast‐provoked elevation of body temperature in rats. The antipyretic effect produced was comparable to that of a standard antipyretic drug, paracetamol. Copyright © 2002 John Wiley & Sons, Ltd.