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Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats
Author(s) -
Sumathy T.,
Subramanian S.,
Govindasamy S.,
Balakrishna K.,
Veluchamy G.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1007
Subject(s) - morphine , pharmacology , lipid peroxidation , antioxidant , pharmacognosy , oral administration , toxicity , traditional medicine , chemistry , liver toxicity , alcohol , medicine , biochemistry , biological activity , in vitro
The protective effect of Bacopa monniera on morphine induced liver antioxidant levels was studied in rats. Oral administration of alcohol extracts of Bacopa monniera induced a significant hepatoprotective effect. In the morphine treated group, a significant increase of lipid peroxidation and a significant decrease in liver antioxidant enzyme levels were observed. Simultaneous administration of morphine and Bacopa extract prevented these alterations. The results of this study showed that Bacopa monniera alcohol extract exerted a hepatoprotective effect against morphine induced liver toxicity. Copyright © 2001 John Wiley & Sons, Ltd.