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Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae)
Author(s) -
Saludes Jonel P.,
Garson Mary J.,
Franzblau Scott G.,
Aguinaldo Alicia M.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1003
Subject(s) - phytol , rubiaceae , cycloartenol , morinda , stigmasterol , fraction (chemistry) , hexane , traditional medicine , chemistry , chromatography , sterol , botany , biology , medicine , biochemistry , cholesterol
A crude ethanol extract and hexane fraction from Morinda citrifolia Linn. (Rubiaceae) show antitubercular activity. The major constituents of the hexane fraction are E ‐phytol, cycloartenol, stigmasterol, β‐sitosterol, campesta‐5,7,22‐trien‐3β‐ol and the ketosteroids stigmasta‐4‐en‐3‐one and stigmasta‐4‐22‐dien‐3‐one. E ‐Phytol, a mixture of the two ketosteroids, and the epidioxysterol derived from campesta‐5,7,22‐trien‐3β‐ol all show pronounced antitubercular activity. Copyright © 2002 John Wiley & Sons, Ltd.