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Brine shrimp lethality assay of Bacopa monnieri
Author(s) -
D'Souza Prashanth,
Deepak Mundkinajeddu,
Rani Padmaja,
Kadamboor Sandhya,
Mathew Anjana,
Chandrashekar Arun P.,
Agarwal Amit
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1001
Subject(s) - bacopa monnieri , brine shrimp , traditional medicine , petroleum ether , saponin , ethanol , chemistry , chloroform , biology , pharmacology , medicine , chromatography , biochemistry , extraction (chemistry) , alternative medicine , pathology
Successive petroleum ether, chloroform, ethanol and water extracts, a saponin rich fraction (SRF) and bacoside A isolated from Bacopa monnieri were tested for brine shrimp lethality. Successive ethanol extracts and SRF showed potent activity. Bacoside A showed the maximum activity with a LC 50 of 38.3 μg/mL. The results confirmed the previous reports of an anticancer effect of Bacopa monnieri and suggest bacoside A as the active constituent. Copyright © 2002 John Wiley & Sons, Ltd.