Brine shrimp lethality assay of  Bacopa monnieri | Zendy

D'Souza Prashanth | Zendy; Deepak Mundkinajeddu | Zendy; Rani Padmaja | Zendy; Kadamboor Sandhya | Zendy; Mathew Anjana | Zendy; Chandrashekar Arun P. | Zendy; Agarwal Amit | Zendy

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Brine shrimp lethality assay of Bacopa monnieri

Author(s) -

D'Souza Prashanth,

Deepak Mundkinajeddu,

Rani Padmaja,

Kadamboor Sandhya,

Mathew Anjana,

Chandrashekar Arun P.,

Agarwal Amit

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1001

Subject(s) - bacopa monnieri , brine shrimp , traditional medicine , petroleum ether , saponin , ethanol , chemistry , chloroform , biology , pharmacology , medicine , chromatography , biochemistry , extraction (chemistry) , alternative medicine , pathology

Successive petroleum ether, chloroform, ethanol and water extracts, a saponin rich fraction (SRF) and bacoside A isolated from Bacopa monnieri were tested for brine shrimp lethality. Successive ethanol extracts and SRF showed potent activity. Bacoside A showed the maximum activity with a LC 50 of 38.3 μg/mL. The results confirmed the previous reports of an anticancer effect of Bacopa monnieri and suggest bacoside A as the active constituent. Copyright © 2002 John Wiley & Sons, Ltd.

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