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Testing non‐inferiority and superiority for two endpoints for several treatments with a control
Author(s) -
Lawrence John
Publication year - 2010
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.468
Subject(s) - clinical endpoint , multiple comparisons problem , placebo , endpoint determination , statistical hypothesis testing , statistics , type i and type ii errors , medicine , mathematics , clinical trial , alternative medicine , pathology
Some multiple comparison procedures are described for multiple armed studies. The procedures are appropriate for testing all hypotheses for comparing two endpoints and multiple test arms to a single control group, for example three different fixed doses compared to a placebo. The procedure assumes that among the two endpoints, one is designated as a primary endpoint such that for a given treatment arm, no hypothesis for the secondary endpoint can be rejected unless the hypothesis for the primary endpoint was rejected. The procedures described control the family‐wise error rate in the strong sense at a specified level α. Copyright © 2010 John Wiley & Sons, Ltd.