Premium
Review of the statistical analysis of the dog telemetry study
Author(s) -
Aylott Mike,
Bate Simon,
Collins Susie,
Jarvis Philip,
Saul Jim
Publication year - 2010
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.454
Subject(s) - telemetry , statistical analysis , statistics , computer science , mathematics , telecommunications
In 2008, the PSI Toxicology Special Interest Group met to discuss the design and analysis of dog telemetry studies. The dog telemetry study is one component of the integrated cardiovascular assessment required by regulatory bodies. Although there are guidelines for these studies, little is said about the statistical analysis. With parameters of interest measured continually over time, in studies typically involving four dogs, the analysis is not straightforward. This has led to many different types of analysis being proposed in the literature, with many different methods applied within the pharmaceutical industry itself. This paper summarizes the PSI Toxicology group's discussions and recommendations around these issues. Copyright © 2010 John Wiley & Sons, Ltd.