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The time course of drug effects
Author(s) -
AlSallami Hesham S.,
Pavan Kumar Venkata V.,
Landersdorfer Cornelia B.,
Bulitta Jurgen B.,
Duffull Stephen B.
Publication year - 2009
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.393
Subject(s) - pharmacodynamics , pharmacokinetics , drug , dosing , pharmacology , underpinning , duration (music) , medicine , computer science , engineering , art , civil engineering , literature
This review aims to introduce the concepts and principles underpinning the time course of drug effects. Models describing the time course of drug concentrations (pharmacokinetic models) and the ensuing concentration‐effect (pharmacodynamics models) as well as the linked time‐effect (pharmacokinetic‐pharmacodynamic models) are introduced. Different types of drug time‐effects models are discussed with examples which aim to explain the time course of onset, duration, and maximal effect that occurs from any given dosing schedule. These drug effects are also described in relation to disease progression models. Copyright © 2009 John Wiley & Sons, Ltd.