Issues with using baseline in last observation carried forward analysis | Zendy

Julious Steven A. | Zendy; Mullee Mark A. | Zendy

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Issues with using baseline in last observation carried forward analysis

Author(s) -

Julious Steven A.,

Mullee Mark A.

Publication year - 2007

Publication title -

pharmaceutical statistics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.421

H-Index - 38

eISSN - 1539-1612

pISSN - 1539-1604

DOI - 10.1002/pst.311

Subject(s) - statistician , imputation (statistics) , annals , missing data , baseline (sea) , statistical analysis , statistics , computer science , mathematics , political science , history , law , ancient history

The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis. Copyright © 2007 John Wiley & Sons, Ltd.

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