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A Sequential procedure for studies comparing multiple doses
Author(s) -
Denne Jon,
Koch Gary
Publication year - 2002
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.28
Subject(s) - continuation , interim , computer science , econometrics , mathematics , law , political science , programming language
Abstract An attractive method of dealing with the multiplicity inherent in studies comparing multiple doses is to use a testing strategy in which hypotheses (or sets of hypotheses) are tested in a prespecified order, with rejection at each step a necessary condition for continuation to the next step. Such a strategy naturally lends itself to interim monitoring. We demonstrate how this may be achieved. Copyright © 2002 John Wiley & Sons, Ltd.