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Comparing two treatments by decision theory
Author(s) -
Longford Nicholas T.
Publication year - 2016
Publication title -
pharmaceutical statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.421
H-Index - 38
eISSN - 1539-1612
pISSN - 1539-1604
DOI - 10.1002/pst.1754
Subject(s) - sample size determination , post hoc , bioequivalence , econometrics , statistics , post hoc analysis , decision theory , computer science , sample (material) , mathematics , medicine , chemistry , dentistry , chromatography , pharmacology , bioavailability
Decision theory is applied to the general problem of comparing two treatments in an experiment with subjects assigned to the treatments at random. The inferential agenda covers collection of evidence about superiority, non‐inferiority and average bioequivalence of the treatments. The proposed approach requires defining the terms ‘small’ and ‘large’ to qualify the magnitude of the treatment effect and specifying the losses (or loss functions) that quantify the consequences of the incorrect conclusions. We argue that any analysis that ignores these two inputs is deficient, and so is any ad hoc way of taking them into account. Sample size calculation for studies intended to be analysed by this approach is also discussed. Copyright © 2016 John Wiley & Sons, Ltd.